Viral Hepatitis

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Management and Treatment of Hepatitis C Viral Infection: Table 10

for Health Care Providers

Table 10. Endpoints for Chronic Hepatitis C Virus (HCV) Treatment

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ENDPOINTDEFINITIONTIME POINT FOR MEASURING HCV RNA
Rapid virologic response (RVR)HCV RNA <50 IU/mL4 weeks after treatment initiation
Early virologic response (EVR)≥2 log10 reduction in pre-treatment HCV RNA12 weeks after treatment initiation
End-of-treatment response (ETR)HCV RNA <50 IU/mLCompletion of therapy
Sustained virologic response (SVR)HCV RNA <50 IU/mL Six months after completion of therapy