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Pregnancy or planned pregnancy in a patient or the patient's sexual partner or unwillingness to use adequate birth control
Documented nonadherence to prior medical treatment or failure to complete HCV disease evaluation appointments and procedures
Inability to self-administer or to arrange appropriate administration of parenteral medication
Severe uncontrolled psychiatric disease, particularly depression with current suicidal risk
Ongoing injection drug use
Ongoing alcohol abuse
*Select patients with clinically decompensated liver disease may be candidates for treatment. NIH Consensus 2000 Statement concluded, "Continued alcohol use during therapy adversely affects response to treatment, and alcohol abstinence is strongly recommended before and during antiviral therapy."