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Table 3. Contraindications to HCV Therapy
- Life-determining extrahepatic disease (malignancy, unstable angina, severe chronic obstructive pulmonary disease)
- Clinically decompensated liver disease*
- Uncontrolled autoimmune disorders
- Pregnancy or planned pregnancy in a patient or the patient's sexual partner or unwillingness to use adequate birth control
- Documented nonadherence to prior medical treatment or failure to complete HCV disease evaluation appointments and procedures
- Inability to self-administer or to arrange appropriate administration of parenteral medication
- Severe uncontrolled psychiatric disease, particularly depression with current suicidal risk
- Ongoing injection drug use
- Ongoing alcohol abuse†
