Therapy against Hepatitis C in Patients with Genotype 1 Infection

* PegIFN alfa-2a 180 mcg per week or PegIFN alfa-2b 1.5 mcg/kg per week. RBV (in two divided doses) with food: <75 kg: 1,000 mg per day or ≥ 75 kg: 1,200 mg per day; alternative weight-based RBV dosing: <65 kg: 800 mg per day, 65-85 kg: 1,000 mg per day, >85-105 kg: 1,200 mg per day, >105 kg: 1,400 mg per day. TVR 750 mg (two 375 mg tablets) orally every 8 h with food (20 g fat).

† A sensitive real-time quantitative HCV RNA assay with a lower limit of detection of <10-15 IU/ml should be used for decision-making to determine treatment duration with response-guided therapy (RGT).