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Viral Hepatitis

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Table 3. Antiviral treatment for chronic hepatitis C in adults

for Health Care Providers

Table 3. Antiviral treatment for chronic hepatitis C in adults

Therapy against Hepatitis C in Patients with Genotype 1 Infection

Generic
(Trade name)
Recommended doseRecommended dose in renal or hepatic dysfunction
BOC, boceprevir; Clcr, creatinine clearance; HCV, hepatitis C virus; PegIFN, peginterferon; PI, protease inhibitor; PO, orally; RBV, ribavirin; SC, subcutaneous; TVR, telaprevir.
PegIFN alfa-2a (Pegasys®) 180 mcg SC once weekly Clcr <30 ml/min: 135 mcg SC once weekly
Hemodialysis: 135 mcg SC once weekly
PegIFN alfa-2b (PEG-Intron®) 1.5 mc/kg SC once weekly Clcr 30-50 ml/min: reduce dose by 25%
Clcr 10-29 ml/min: reduce dose by 50%
RBV (Copegus®, Rebetol®, Ribasphere®, RibaPak®)

Genotype 1:
1,000 mg (if ≤ 75 kg) or 1,200 mg (if >75 kg) PO daily in two divided doses,

Or

<65 kg: 800 mg PO daily in two divided doses
65-85 kg: 1,000 mg PO daily in two divided doses
>85-105 kg: 1,200 mg PO daily in two divided doses
>105 kg: 1,400 mg PO dailsy in two divided doses

Genotype 2 or 3:
800 PO daily in two divided doses

Clcr 30-50 ml/min: 200 mg PO daily, alternating with 400 mg PO daily
Clcr <30 ml/min: 200 mg PO daily
PIs for treatment of HCV genotype 1
BOC (Victrelis™) 800 mg (4 x 200 mg capsules) PO every 7-9 apart with food in combination with PegIFN-RBV following a 4-week lead-in with PegIFN-RBV Dose adjustments not necessary for renal or hepatic impairment (Child-Pugh <7)
TVR (Incivek™) 750 mg (2 x 375 mg tablets) PO every 7-9 h with food (20 grams fat) for 12 weeks, plus PegIFN-RBV for 24 or 48 weeks Dose adjustments not necessary for renal or hepatic impairment (Child-Pugh <7)