Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu links, hit the down arrow. You will now be able to tab or arrow up or down through the submenu options to access/activate the submenu links.

Viral Hepatitis

Quick Links

Veterans Crisis Line Badge
My healthevet badge

Table 6. HCV PI (BOC or TVR): RGT criteria and futility rules

for Health Care Providers

Table 6. HCV PI (BOC or TVR): RGT criteria and futility rules

Table 6. HCV PI (BOC or TVR): RGT criteria and futility rules (34, 35)
BOC-PegIFN/RBVTVR-PegIFN/RBV
HCV, hepatitis C virus; PegIFN, peginterferon; PI, protease inhibitor; RBV, ribavirin; RGT, response-guided therapy; TVR, telaprevir.
Candidates for RGT Noncirrhotics:
Treatment-naive: 28 weeks
Prior relapser/partial responder: 36 weeks
Noncirrhotics:
Treatment-naive: 24 weeks
Prior relapser: 24 weeks
Criteria for RGT HCV RNA undetectable (<10-15 IU/ml) weeks 8-24 HCV RNA undetectable (<10-15 IU/ml) weeks 4 and 12
Futility rules (stop all treatment if any of the following occur)

Week 12: HCV RNA ≥100 IU/ml

Or

Week 24: HCV RNA detectable

Or

HCV RNA rebounds at any timepoint (≥1 log10increase from the nadir HCV RNA)

Week 4 or 12: HCV RNA >1,000 IU/ml

Or

Week 24: HCV RNA detectable

Or

HCV RNA rebounds at any timepoint (≥1 log10 increase from the nadir HCV RNA)