Antiviral Treatment Eligibility

Pretreatment Assessment

1. Necessary Evaluations
• Medical history
• Psychiatric history
• Screening for depression and alcohol use
• Biochemical markers of liver injury and synthetic dysfunction
  • Serum ALT
  • Serum albumin
  • Serum bilirubin (particularly direct)
  • Prothrombin time
• Hemoglobin, hematocrit, total WBC, WBC with differential and platelet count
• Thyroid function tests
• Serum creatinine
• Serum glucose or HgbA1C in diabetic patients
• Pregnancy test (in women of child-bearing potential)
• HIV serology
• Serum HBsAg, anti-HBs, anti-HBc (total) and anti-HAV (total)
• Quantitative HCV RNA
• HCV genotype
• Previous antiviral therapies and response
• ECG in preexisting cardiac disease
2. Highly recommended evaluations
• Liver biopsy to stage severity of disease (especially in patients with genotype 1 infection)
• Eye examination for retinopathy in patients with diabetes or hypertension
• Serum ferritin, iron saturation and serum ANA
• Urine toxicity screen for opiates, cocaine, and amphetamines

Next: Pretreatment Counseling