Antiviral TX Strategy

Genotype 2-3

1. Peginterferon alfa 2a (Pegasys) 180 mcg SC once weekly (regardless of weight) OR
2. Peginterferon alfa 2b (PEG-Intron) 1.5 mcg/kg SC once weekly OR

PEG-IFN alfa 2b Dosing

WT (lbs)	PEG vial to use (ug/0.5mL)	PEG dose (mL)
<88	50	0.5
88-110	80	0.4
111-141	80	0.5
142-166	120	0.4
167-187	120	0.5
>187	150	0.5

3. Ribavirin 800 mg QD (400 mg PO BID)
4. Duration of therapy
• Standard treatment of duration is 24 weeks
• For patients with low pretreatment HCV RNA (<600,000 IU/mL) who are not tolerating therapy, 16 weeks of treatment may be sufficient
• For patients with genotype 3 and high viral load (>600,000) IU/mL) or steatosis, treatment beyond 24 weeks may improve response

Next: Follow-Up Lab Monitoring