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Viral Hepatitis

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Hepatitis C Quicknotes: Genotype 2-3

for Health Care Providers

Antiviral TX Strategy

Genotype 2-3

  1. Peginterferon alfa 2a (Pegasys) 180 mcg SC once weekly (regardless of weight) OR
  2. Peginterferon alfa 2b (PEG-Intron) 1.5 mcg/kg SC once weekly OR
  3. PEG-IFN alfa 2b Dosing
    WT (lbs)PEG vial to use (ug/0.5mL)PEG dose (mL)
    <88500.5
    88-110800.4
    111-141800.5
    142-1661200.4
    167-1871200.5
    >1871500.5
  4. Ribavirin 800 mg QD (400 mg PO BID)
  5. Duration of therapy
    • Standard treatment of duration is 24 weeks
    • For patients with low pretreatment HCV RNA (<600,000 IU/mL) who are not tolerating therapy, 16 weeks of treatment may be sufficient
    • For patients with genotype 3 and high viral load (>600,000) IU/mL) or steatosis, treatment beyond 24 weeks may improve response

Next: Follow-Up Lab Monitoring