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Comparison of Side Effects in 3 Different HCV Treatment Regimens from Randomized Controlled Clinical

for Health Care Providers

Table 1. Comparison of Side Effects in 3 Different HCV Treatment Regimens from Randomized Controlled Clinical Trials

Back to Interferon and Ribavirin Treatment Side Effects

Peginterferon alfa-2b 1.5 mcg/kg weekly + Ribavirin 800 mg daily

Manns, et al. The Lancet, 2001(3)

(N = 511)

Peginterferon alfa-2a 180 mcg weekly + Ribavirin 1000-1200 mg daily, weight based

Fried, et al. NEJM, 2002(4)

(N = 453)

Interferon alfa-2b 3 million units three times weekly + Ribavirin 1000-1200 mg daily, weight based

McHutchinson, et al. NEJM, 1998(2)

(N = 228)

Adverse Event(% Affected)

# The % of patients with neutropenia was not reported or described, but authors included comment, "the leukocute counts decreased during therapy but the mean value remained within the normal range."

* The % of patients with thrombocytopenia was not reported, but authors included comment, "the median platelet counts decreased progressively during first either weeks of peginterferon 2a plus ribavirin, before stabilizing, After treatment was completed, the median platelet counts returned to normal within four weeks. 1 patient had serious bleeding and 4 discontinued treatment due to thrombocytopenia."

Constitutional
Fatigue645470
Headache624766
Myalgias564264
Fever464341
Arthralgias342733
Gastrointestinal
Nausea432946
Anorexia322125
Diarrhea22n/a22
Psychiatric
Depression312236
Irritability352432
Insomnia403739
Dermatological
Pruritus292219
Dermatitis/Rash242128
Alopecia362832
Laboratory
Anemia9239
Neutropenia1821#
Thrombocytopenia3*5
Endocrinen/an/an/a
Respiratory
Cough17n/a14
Dyspnea26n/a18