Viral Hepatitis and Liver Disease Website Course

Evaluating Liver Test Abnormalities

Understanding the Pathophysiology of Liver Disease

for Health Care Providers


Back to Acute Cholestasis

Severe bacterial infection can impair bile secretion and give rise to cholestasis. Although alkaline phosphatase elevation can be seen in sepsis-induced cholestasis, the most common abnormality is isolated hyperbilirubinemia. Other potential causes of cholestasis need to be excluded before the diagnosis of sepsis-related cholestasis can be made. In the presence of elevations in alkaline phosphatase, cholangitis as the cause of fever should be investigated.