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Viral Hepatitis and Liver Disease

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HCV DAA Classes

for Health Care Providers

Classification of Direct-Acting Antiviral Agents in HCV Treatment Regimens - Hepatitis C

There are 4 targets on the hepatitis C virus (HCV) that direct-acting antiviral (DAA) medications attack to destroy the virus. Each DAA medication attacks one of these targets; combination DAA tablets attack more than one target. DAA medications are classified based on which mechanism they use against HCV. Recognizing the DAA medication class(es) becomes particularly important when retreating a patient for HCV who has been previously treated with a DAA-based therapy.

For details on choosing treatment regimens for individual patients, see the Veterans Health Administration Chronic HCV Infection Treatment Considerations.

Trade and Generic Names for HCV DAA Medications
DAA Trade NameDAA Generic NameAbbreviation
Sovaldi®sofosbuvirSOF
Olysio®simepravirSIM
Harvoni®ledipasvir/sofosbuvir LDV/SOF
Viekira Pak®paritaprevir/ritonavir/ombitasvir + dasabuvir PrOD
Technivie®paritaprevir/ritonavir/ombitasvirPrO
Zepatier®elbasvir/grazoprevirEBR/GZR
DaklinzadaclatasvirDCV
Epclusa®sofosbuvir/velpatasvirSOF/VEL
VoseviTMsofosbuvir/velpatasvir/voxilaprevirSOF/VEL/VOX
MavyretTMglecaprevir/pibrentasvirGLE/PIB
HCV DAA Treatment Regimens by Class
DAA Treatment RegimenNS3/4A Protease InhibitorNS5B Non-Nucleoside Polymerase InhibitorNS5B Nucleotide Polymerase InhibitorNS5A Polymerase Inhibitor
RBV = ribavirin; PEG-IFN = pegylated interferon
SOF + RBV ± PEG-IFN
SOF + SIM ± RBV
LDV/SOF ± RBV
PrOD ± RBV
PrO
EBR/GZR ± RBV
DCV + SOF ± RBV
SOF/VEL ± RBV
SOF/VEL/VOX
GLE/PIB
Number of DAA Tablets Per Day By HCV Treatment Regimen
Regimen Generic NameHow Many DAA Per Tablet?How Many DAA Tablets Taken Per Day?Ribavirin Needed?*
*RBV adds 4-6 capsules per day
SOF ± PEG-IFN1 DAA per tablet1 tabletribavirin required
SOF + SIM1 DAA per tablet + 1 DAA per tablet2 tabletssometimes
LDV/SOF2 DAA per tablet1 tabletsometimes
PrOD2 DAA in 1st tablet + 1 DAA in 2nd tablet4 tabletssometimes
PrO2 DAA per tablet2 tabletsno ribavirin
EBR/GZR2 DAA per tablet1 tabletsometimes
DCV + SOF1 DAA per tablet + 1 DAA per tablet2 tabletssometimes
SOF/VEL2 DAA per tablet1 tabletsometimes
SOF/VEL/VOX3 DAA per tablet1 tabletno ribavirin
GLE/PIB2 DAA per tablet3 tabletsno ribavirin