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Viral Hepatitis and Liver Disease

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HCV DAA Classes

for Health Care Providers

Classification of Direct-Acting Antiviral Agents in HCV Treatment Regimens - Hepatitis C

There are 3 targets on the hepatitis C virus (HCV) that currently recommended direct-acting antiviral (DAA) medications attack to destroy the virus. Each DAA medication attacks one of these targets; combination DAA tablets attack more than one target. DAA medications are classified based on which mechanism they use against HCV. Recognizing the DAA medication class(es) becomes particularly important when retreating a patient for HCV who has been previously treated with a DAA-based therapy. There are 3 classes of currently recommended DAA medications:

  • NS3/4A protease inhibitors
  • NS5A polymerase inhibitors
  • NS5B polymerase inhibitors

For details on choosing treatment regimens for individual patients, see the Veterans Health Administration Chronic HCV Infection Treatment Considerations.

Trade and Generic Names for First Line HCV DAA Medications
DAA Trade NameDAA Generic NameAbbreviation
Harvoni®ledipasvir/sofosbuvir LDV/SOF
Zepatier®elbasvir/grazoprevirEBR/GZR
Epclusa®sofosbuvir/velpatasvirSOF/VEL
VoseviTMsofosbuvir/velpatasvir/voxilaprevirSOF/VEL/VOX
MavyretTMglecaprevir/pibrentasvirGLE/PIB
HCV DAA Treatment Regimens by Class
DAA Treatment RegimenNS3/4A Protease InhibitorNS5B Nucleotide Polymerase InhibitorNS5A Polymerase Inhibitor
RBV = ribavirin
LDV/SOF ± RBV
EBR/GZR ± RBV
SOF/VEL ± RBV
SOF/VEL/VOX
GLE/PIB
Number of DAA Tablets Per Day By HCV Treatment Regimen
Regimen Generic NameHow Many DAA Per Tablet?How Many DAA Tablets Taken Per Day?Ribavirin Needed?*
*RBV adds 4-6 capsules per day
LDV/SOF21sometimes
EBR/GZR21sometimes
SOF/VEL21sometimes
SOF/VEL/VOX31no
GLE/PIB23no