Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu links, hit the down arrow. You will now be able to tab or arrow up or down through the submenu options to access/activate the submenu links.

Viral Hepatitis


Quick Links

Veterans Crisis Line Badge
My healthevet badge
EBenefits Badge

Table 4. SVR rates in genotype 1-infected patients treated with PegIFN/RBV +/- BOC or TVR

for Health Care Providers


You are viewing outdated content. This information may no longer be accurate or relevant and is provided for research or recordkeeping purposes only.

Table 4. SVR rates in genotype 1-infected patients treated with PegIFN/RBV +/- BOC or TVR

Therapy against Hepatitis C in Patients with Genotype 1 Infection

Study cohort, NSVR to PI/PegIFN/RBV (arm 1 of trial)SVR to PI/PegIFN/RBV (arm 2 of trial)SVR with PegIFN/RBV
BOC, boceprevir; eRVR, extended rapid virologic response; HCV, hepatitis C virus; PegIFN, peginterferon alfa; PI, protease inhibitor; RBV, ribavirin; RGT, response-guided therapy; SVR, sustained virologic response; TVR, telaprevir.
BOC (SPRINT-2), SVR% 63 66 38
N = 1,099 (11) BOC/PegIFN/RBV RGT BOC/PegIFN/RBV 44 weeks PegIFN/RBV 48 weeks
TVR (ADVANCE), SVR% 69 75 44
N = 1,088 (12) TVR for 8 weeks/PegIFN/RBV RGT TVR for 12 weeks/PegIFN/RBV RGT PegIFN/RBV 48 weeks
N = 540 (49) TVR for 12 weeks/PegIFN/RBV (24 total weeks) if eRVR TVR for 12 weeks/PegIFN/RBV(48 total weeks) if eRVR -
TVR (REALIZE), SVR% overall - -
N = 662 (13) NA 64-66 17
TVR for 12 weeks/PegIFN/RBV (48 weeks total)
Prior relapsers (SVR%) - 83-88 24
Prior partial responders (SVR%) - 54-59 15
Prior null responders (SVR%) - 29-33 5
BOC (RESPOND-2), SVR% overall
N = 403 (14) 59 66 21
BOC/PegIFN/RBV (48 weeks total)
Prior relapsers (SVR%) 69 75 29
Prior partial responders (SVR%) 40 52 7