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Viral Hepatitis


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Hepatitis C Medications: Boceprevir and Telaprevir

for Health Care Providers

Medications: Boceprevir and Telaprevir

Summary: Boceprevir and Telaprevir

  • Approved by FDA in 2011
  • The first 2 direct-acting antivirals approved for hepatitis C
  • Only for genotype 1
  • Must be taken with pegylated interferon and ribavirin
  • Represent a new chapter in hepatitis C treatment with significantly improved SVR rates in difficult to treat patients, compared to pegylated interferon and ribavirin alone
  • Brought a new possibility for genotype 1 patients to be retreated when they had previously failed or relapsed
  • Limited by their complex pill regimen, high side-effect burden, and difficult and intensive monitoring.

News and Alerts

Clinician Resources

Patient Education

  • New Therapies for Hepatitis C (brochure)
    A guide for patients who are considering taking boceprevir or telaprevir. Includes information on how the drugs work, how they should be taken, what the common side effects are, and questions to discuss with providers. March 2012
  • Hepatitis C Medications: A Review and Update for Patients
    Web page that describes how hepatitis C is treated, the possible side effects, the likelihood of a positive response, and why some patients get treated and others don't. May 6, 2011
  • Triple Therapy Workbooks (30-page booklets)
    Workbooks designed for patients to keep on hand throughout their treatment course with boceprevir or telaprevir. Colorful medication schedules illustrate how many of each pill are taken at a given time, when pills must be accompanied by food, with advice on how to plan the times to take each dose. July 2012
  • Taking Your Hepatitis C Triple Therapy (1-page handout)
    One-page printable handouts for providers to give to patients taking either boceprevir or telaprevir, with tips on how and when to take the medications, and what to do if you miss a dose. February 2012

Journal Articles