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Evaluating Liver Test Abnormalities

Understanding the Pathophysiology of Liver Disease

for Health Care Providers

Evaluation Algorithm

Hover over each oval for more information and select a pattern, duration, and classification. Clicking on the classification will take you to additional information.

The Pattern stage of the evaluation algorithm showing that after an abnormal liver test, the patient will have either predominant elevation of ALT and AST or Predominant elevation of alkaline phosphatase (Cholestatic pattern). Click on the relevant pattern to proceed.Abnormal liver tests
The Pattern stage of the evaluation algorithm showing that after an abnormal liver test, the patient will have either predominant elevation of ALT (SGPT) and AST (SGOT) (Hepatocellular pattern); or Predominant elevation of alkaline phosphatase (Cholestatic pattern). Click on the relevant pattern to proceed.PatternPredominant elevation of alkaline phosphate (Cholestatic pattern) - not selected
The two options of the Pattern state with Predominant elevation of ALT (SGPT) and AST (SGOT) highlighted.Predominant elevation of ALT (SGPT) and AST (SGOT) (Hepatocellular pattern) - highlightedPredominant elevation of alkaline phosphate (Cholestatic pattern) - not selected
The two options of the Pattern state with Predominant elevation of alkaline phosphatase highlightedPredominant elevation of ALT (SGPT) and AST (SGOT) (Hepatocellular pattern) - not highlightedPredominant elevation of alkaline phosphate (Cholestatic pattern) - highlighted
the word duration underlined
The Duration stage shows options for: Less than 6 months (Acute hepatocellular injury); or More than 6 months (Chronic hepatocellular injury).Less than 6 months (Acute hepatocellular injury)- not highlightedMore than 6 months (Chronic hepatocellular injury) - not highlighted
The Duration stage with Less than 6 months (Acute hepatocellular injury) highlightedOption selected: Less than 6 months (Acute hepatocellular injury)- highlightedOption (not selected)- More than 6 months (Chronic hepatocellular injury)
The Duration stage with More than 6 months (Chronic hepatocellular injury) highlightedLess than 6 months (Acute hepatocellular injury)- not highlightedOption (selected)- More than 6 months (Chronic hepatocellular injury)
The Duration stage shows options for: Less than 6 months; or More than 6 monthsLess than 6 monthsMore than 6 months
The Duration stage with Less than 6 months highlightedLess than 6 months (selected)More than 6 months
The Duration stage with More than 6 months highlightedLess than 6 monthsMore than 6 months (selected)
the word Classification underlined
The Classification stage with options for: Marked ALT/AST elevation (greater than 15 times ULN); or Mild to Moderate ALT/AST elevation (less than 15 times ULN). ULN stands for Upper limit of normalMarked ALT/AST elevation (more than 15 times ULN (upper limit of normal))Mild to Moderate ALT/AST elevation (less than 15 times ULN (upper limit of normal))
The Classification stage with options for: Chronic hepatocellular injury; or Acute on chronic hepatocellular injury (worsening ALT/AST elevation).Chronic hepatocellular injuryActe on chronic hepatocellular injury (worstening ALT/AST elevation)
The Classification stage with Acute Cholestasis highlighted.Acute Cholestasis
The Classification stage with Chronic injury highlighted.Chromnic Injury (highlighted)
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