Viral Hepatitis and Liver Disease Website Course
Evaluating Liver Test Abnormalities
Understanding the Pathophysiology of Liver Disease
for Health Care Providers
Clinical Course Question
Hepatitis A serologies
Acute viral hepatitis A is one of the most common causes of acute hepatocellular injury. The diagnosis is made with a positive IgM hepatitis A antibody (IgM anti-HAV). While the IgG type hepatitis A antibody (IgG anti-HAV) signifies history of past exposure to viruses, the IgM type is specific for an acute infection.
Hepatitis B serologies
Acute viral hepatitus B is one of the most common causes of acute hepatocellular injury, particularly on this age group. The diagnosis is made with a positive hepatitis B antigen (HBsAg) and/or a positive IgM hepatitis core antibody (anti-HBc).
Prothrombin time (PT) is a measure of liver synthetic function. It should be monitored closely in patients with severe hepatitis. Patients who exhibit signs and symptoms of hepatic dysfunction (encephalopathy and prolonged PT) should be admitted to the hospital for close monitoring. Liver transplantation should also be considered in patients with fulminant hepatic failure.
The patient's alk phos was not elevated and a GGT was not indicated. GGT is useful in confirming the hepatic source of alkaline phosphatase elevation in cholestatic liver injury.
Anti-mitochondrial antibody is a serological marker for primary biliary cirrhosis, a chronic cholestatic disease.