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Viral Hepatitis and Liver Disease

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Hepatitis B Virus Tests and Interpretation

for Health Care Providers

Hepatitis B Virus Tests and Interpretation - Hepatitis B

TestSusceptibleImmune due to Successful VaccinationImmune due to Resolved infectionAcute HBVPrior HBV and isolated HBcAb+
*Test is only needed if patient is HBsAg positive or there is suspicion of occult HBV.
HBV surface antigen (HBsAg)NegNegNegPosNeg
HBV surface antibody (HBsAb)NegPosPosNegNeg
HBV core antibody IgG (HBcAb IgG)negNegPosPosPos
HBV core antibody IgM (HBcAb IgM)NegNegNegPosNeg
HBeAg*Not applicableNot applicableNot applicableNegNeg
HBeAb*Not applicableNot applicableNot applicableNegPos
HBV DNA*Not applicableNot applicableNot applicableNeg or PosNeg
ALT*Not applicableNot applicableNot applicableElevatedTypically Normal
TestOccult HBV, with loss of HBsAgChronic Inactive HBVChronic HBV, e-Ag positiveChronic HBV, e-Ag negativeReactivation of Chronic HBV
*Test is only needed if patient is HBsAg positive or there is suspicion of occult HBV.
HBsAgNegPosPosPosPos
HBV surface antibody (HBsAb)NegNegNegNegNeg
HBV core antibody IgG (HBcAb IgG)PosPosPosPosPos
HBV core antibody IgM (HBcAb IgM)NegNegNegNegNeg
HBeAg*NegNegPosNegPos or Neg
HBeAb*PosPosNegPosPos or Neg
HBV DNA*PosNeg or Low LevelPosPosPos
ALT*Variable (Normal-Elevated)NormalVariable (Normal-Elevated)Variable (Normal-Elevated)Elevated