Hepatitis C Treatment Considerations - Viral Hepatitis and Liver Disease
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Viral Hepatitis and Liver Disease


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Hepatitis C Treatment Considerations

for Veterans and the Public

Chronic Hepatitis C Virus (HCV) Infection: Treatment Considerations - Hepatitis C


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This revision (August 27, 2018) incorporates updates to treatment regimens for chronic hepatitis C virus (HCV) infection, including:

  • Algorithms for HCV genotype 1 treatment-experienced patients (Figure 1)PDF icon
  • A new section on acute HCVPDF icon
  • Updates to liver transplant informationPDF icon
  • Revisions to tables showing drug-drug interactions to provide clinicians with guidance on the concomitant use of HCV drugs and other drugs, including HIV antiretroviral agents (Table 23PDF icon and Table 24PDF icon).

The Panel continues to recommend:

  • HIV/HCV-coinfected patientsPDF icon receive the same HCV antiviral regimens as HCV-monoinfected patients unless ledipasvir/sofosbuvir is being considered, in which case a 12-week regimen should be used (instead of an 8-week regimen).
  • HBV testing and monitoring prior to starting HCV DAA. Details can be found in Appendix DPDF icon.