for Health Care Providers
Monitoring Patients Not on Treatment - Hepatitis B
HBeAg-Positive, Elevated ALT, Without Cirrhosis
* Cut off (upper limit of normal = ULN) of a normal ALT ≤ 35 U/L for males and ≤ 25 U/L for females is recommended to guide management decision
** Additionally monitor HBeAg every 6-12 mo
*** Other factors in decision to treat elevated ALT that is < 2x upper limit and HBV DNA is < 20,000: Age > 40, family history of HCC, previous treatment history, presence of extrahepatic manifestations, presence of cirrhosis
Adapted from: Terrault NA, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560-1599. doi: 10.1002/hep. 29800.